Antibody responses to polymorphic Plasmodium falciparum merozoite antigens in Malawian children with severe and uncomplicated malaria.

ABSTRACT:

Background

The magnitude and specificity of naturally acquired antibody responses to Plasmodium falciparum merozoite surface proteins could influence the clinical presentation of malaria in young children. As many putative targets of immunity are structurally diverse, lack of antibodies to the infective parasite genotype could lead to immune evasion, higher parasitaemia and more severe clinical manifestation of the disease.

Methods

The degree of concordance between IgG responses to polymorphic and dimorphic antigenic regions of vaccine candidates MSP-1 and MSP-2 and the infective parasites detected by PCR was investigated in 269 paediatric patients presenting with cerebral malaria (CM), severe malarial anaemia (SMA) or uncomplicated malaria (UM) in Blantyre, Malawi.

Resul

SUBMITTER: Dobano C 

PROVIDER: S-EPMC12621371 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature