Comprehensive androgen-dependent transcriptome analysis in human genital tissue.

ABSTRACT:

Background

Androgen signalling through the androgen receptor (AR) is crucial for male genital development. Disruptions in this pathway are associated with androgen insensitivity syndrome (AIS), which is typically caused by mutations in the AR gene, although the underlying genetic mechanisms remain unknown in many cases. To better understand androgen-dependent transcriptional changes in human genital tissue, we performed transcriptomic profiling of foreskin- and scrotum-derived human genital skin fibroblasts (GSFs) treated with dihydrotestosterone.

Results

Differential gene expression analysis revealed 409 and 260 reproducibly up-regulated genes in foreskin- and scrotum-derived GSFs, respectively. GSFs from individuals with complete androgen insensitivity syndrome, carrying i

SUBMITTER: Sivaprasad R 

PROVIDER: S-EPMC12621392 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature