Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism.

ABSTRACT:

Background

Coptidis Rhizoma, the rhizome of Coptis chinensis Franch., has long been employed in the treatment of diabetes. Its active component, berberine, has been utilized in clinical practice; however, the underlying mechanisms of its protective effects remain to be fully elucidated.

Methods

Metabolomics and lipidomics analyzed plasma metabolite and lipid changes in mice fed a high-fat diet and treated with 25 mg/kg/day berberine for three months. Metagenomics and microbiota transplantation identified gut microbiota responding to berberine. Co-administration of berberine and Akkermansia was studied for metabolic effects, analyzing plasma and fecal metabolomics.

Results

Berberine reduced triglycerides and cholesterol, showing metabolic protective effects. Metagenomi

SUBMITTER: Hang WJ 

PROVIDER: S-EPMC12621396 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature