Probiotic Lactobacillus casei Inhibits Oral Squamous Cell Carcinoma Growth and Induces Apoptosis In Vitro.

ABSTRACT:

Objectives

Oral squamous cell carcinoma (OSCC) is a significant cause of mortality. Probiotic bacteria like Lactobacillus casei have shown anti-cancer and immune-modulatory properties. This study aimed to investigate the anti-proliferative effects of L. casei on OSCC and its apoptotic mechanisms.

Methods

Human head and neck squamous cell carcinoma (HNSCC) cells of the oral cavity (HNO97 cell line) were exposed to L. casei at concentrations of 1 × 10⁸ CFU/ml and 5 × 10⁷ CFU/ml, and the viability of HNO97 cells was assessed by MTT assay. Bacterial attachment was studied by live confocal microscopy, and apoptosis was confirmed by Nexin staining. The underlying mechanisms of apoptosis were studied by examining the expression of the TRAIL gene and its encodi

SUBMITTER: Rehaman TA 

PROVIDER: S-EPMC12621436 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature