A national cross-sectional analysis of surveillance drug resistance mutations among recently diagnosed antiretroviral naive Brazilian people with HIV.

ABSTRACT:

Background

Brazil pioneered free and universal HIV antiretroviral therapy (ART) access in 1996. This study evaluated the prevalence of surveillance drug resistance mutations (SDRM) among individuals newly diagnosed with HIV and initiating ART.

Methods

Using WHO HIV Threshold Survey methodology, participants were recruited from seven major cities, representing all Brazilian macro-regions. Dried blood spots collected between August 2021 and November 2023 were transported at room temperature to a central laboratory for genotyping.

Findings

A total of 327 samples were analyzed, 271 (82.9%) were males. The self-reported ethnic distribution was obtained from 257 people, including 92 white (35.8%), 115 brown (44,7%), 46 black (17.9%), 2 indigenous (0.8%), and 2 Asian (0.8%)

SUBMITTER: Caldeira DB 

PROVIDER: S-EPMC12621447 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature