Improved and Novel Methods for Investigating Organophosphate Esters in Particulate Matter.

ABSTRACT: A pressurized liquid extraction (PLE) method for the extraction of 31 organophosphate esters (OPEs) and novel organophosphate esters (NOPEs) has been developed. Unlike previously published methods, this method utilizes the high-throughput nature of PLE (as opposed to Soxhlet or sonication methods) without using potentially harmful organic solvents like methylene chloride. Combinations of hexane and acetone and hexane and ethyl acetate at various temperatures were examined. Extracts were concentrated and analyzed via gas chromatography-mass spectrometry. The final optimized method utilized 1:1 v/v hexane/ethyl acetate at 100 °C for three static cycles (5 min each) at 80% flush volume and a 100 s N₂ purge. This provided average surrogate corrected target analyte perc

SUBMITTER: Gathof A 

PROVIDER: S-EPMC12621544 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature