Peripheral immune indicators and their predictive value in disease progression or relapse of pediatric Langerhans cell histiocytosis.

ABSTRACT:

Objective

Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm in which the inflammatory microenvironment plays a crucial role in the development and progression of disease. The prognostic value of circulating lymphocyte subsets and cytokines remains uncertain.

Methods

The authors retrospectively analyzed baseline peripheral lymphocyte subsets and serum cytokines in 330 consecutive pediatric patients. Immune profiles were compared across disease extent, clinical events, and biological features. Prognostic associations with progression-free survival (PFS) were tested using univariable and multivariable models.

Results

Peripheral immune profiles varied with disease extent. Patients with multisystem risk-organ involvement (MS RO⁺) had fe

SUBMITTER: Li HL 

PROVIDER: S-EPMC12621562 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature