Surface-modified iron oxide nanoprobes in biomedical scaffolds.

ABSTRACT: Magnetic (PU) scaffolds incorporating superparamagnetic iron oxide nanoparticles (SPIONs) offer a promising platform for localized cancer therapy. By enhancing the functional performance of these scaffolds through surface modification of iron oxide nanoprobes, their biomedical utility-particularly in targeted therapeutic applications-can be significantly improved. In this study, we report the synthesis and characterization of magnetite nanoparticles (Fe₃O₄ NPs) functionalized with biocompatible coatings-citrate, polyethylene glycol (PEG), oleic acid (OA), and aluminum hydroxide (Al(OH)₃)-and their integration into porous PU scaffolds via a salt-leaching/phase-inversion method. Among all tested formulations, SPIONs@Al(OH) demonstrated superior colloid

SUBMITTER: Gonzalez-Gomez MA 

PROVIDER: S-EPMC12621608 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature