Whole-chromosome duplications drive antimicrobial resistance in <i>Aspergillus fumigatus</i>.

ABSTRACT: Aneuploidy causes genome plasticity and enables adaptive responses that confer drug resistance in eukaryotes ranging from fungal pathogens to human cancer cells. Aspergillus fumigatus is a soil-resident fungus and the most common cause of invasive fungal infections globally. Aspergillosis has an alarmingly high mortality rate due in part to treatment failure resulting from widespread antimicrobial resistance and an ability of the fungus to dynamically adapt to changing environmental and host conditions. Our understanding of these treatment failures is hindered by gaps in knowledge about how this organism adapts to resist antimicrobial stress. We find that exposure to FK506, an antifungal and immunosuppressive compound produced by Streptomyces, selects for whole-chromosome ane

SUBMITTER: Lehmann AE 

PROVIDER: S-EPMC12621686 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature