Multimodal MR Imaging for quantification of brain lipid in mice at 9.4T.

ABSTRACT:

Background

Advanced MR imaging techniques like steady state Nuclear Overhauser enhancement (ssNOE), transient NOE (tNOE), and myelin water fraction (MWF) provide a non-invasive way to assess the biochemical and structural integrity of brain tissue. Their sensitivity to endogenous lipids and macromolecules allows for the early detection of neuropathological changes, making them valuable tools in studying brain health and disease progression. In this study, we systematically evaluate the repeatability and sensitivity of NOE_MTR, tNOE, and MWF for quantifying lipid and myelin content in the brains of wild-type (WT) mice, correlating the results with immunohistochemistry (IHC).

Methods

Five 6-month-old C57BL6/J mice were imaged using 3D-NOE, and four mice underwent ima

SUBMITTER: Khokhar SK 

PROVIDER: S-EPMC12621774 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature