Gastric epithelium from <i>BRCA1</i> and <i>BRCA2</i> carriers harbors increased double-stranded DNA damage and augmented growth.

ABSTRACT: An accumulating body of evidence suggests carriers of a pathogenic germline variant (PGV) in BRCA1 or BRCA2 have increased gastric cancer (GC) risk. BRCA1 and BRCA2 are tumor suppressor genes involved in promoting homologous recombination to repair double-stranded DNA breaks. The aim of this investigation was to identify differences within the gastric epithelium and in patient-derived gastric organoids (PDGOs) between BRCA1 and BRCA2 carriers and non-carriers to determine if evidence of early gastric carcinogenesis exists amongst these carriers. First, using gastric epithelial biopsies, BRCA2 carriers were found to harbor higher expression of the proliferative marker Ki-67 within the antral gastric epithelium and strikingly, biopsies from bo

SUBMITTER: Buckley KH 

PROVIDER: S-EPMC12621815 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature