Minor Cannabinoids CBD, CBG, CBN and CBC differentially modulate sensory neuron activation.

ABSTRACT: The use of minor cannabinoids has been advanced, in part, by the idea of providing relief from pain and inflammation without the burden of unwanted psychogenic effects associated with Δ⁹THC. In this regard, investigators have focused on the effects of minor cannabinoid activation / desensitization of peripheral sensory neurons on nociceptive signaling and/or peripheral inflammation. With a focus on peripheral nociception, four common minor cannabinoids: cannabidiol (CBD), cannabigerol (CBG), cannabinol (CBN) and cannabichromene (CBC) were studied in primary cultures of mouse Dorsal Root Ganglion (DRG) neurons. We queried if calcium responses induced by the four cannabinoids differed in potency of activation, neuronal size preference, and dose-response relationships. Additionally

SUBMITTER: Rabl K 

PROVIDER: S-EPMC12621841 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature