Patient-specific functional brain architecture explains cortical patterns of tau PET in Alzheimer's disease.

ABSTRACT: The spatial distribution of tau pathology, the core driver of neurodegeneration in Alzheimer's disease (AD), varies markedly across individuals. While tau is thought to spread along brain networks, the role of inter-individual variability in shaping these patterns remains underexplored. Using resting-state fMRI and tau-PET from 805 participants across the AD continuum, we studied whether subject-specific functional connectivity (FC) profiles enhance the characterization of tau deposition patterns. A hybrid approach integrating individual and group-average FC outperformed both alone, particularly in symptomatic individuals and at finer spatial resolutions, the latter underscoring a critical but often overlooked role of spatial scale. Individualized FC also better captured individual tau top

SUBMITTER: Behjat HH 

PROVIDER: S-EPMC12621874 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature