Engineered antimicrobial-derived peptides to manipulate mixed microbial systems.

ABSTRACT: Due to complexity of microbial communities and coarseness of currently available manipulation techniques (e.g. transplantation, antibiotic-treatment), it is often difficult to fully elucidate the interactions between members that define community structure and function from the top-down. Thus, it is imperative to be able to observe and manipulate subpopulations within microbial communities to enable a fine-detail understanding of the full-spectrum and mechanism of community functions. However, there is a technological gap that prevents targeted manipulation of subpopulations within intact microbial mixtures and communities. In this work, we develop molecular probes to manipulate specific subpopulations within multispecies microbial populations and validate these methods using model synthet

SUBMITTER: Trivedi VD 

PROVIDER: S-EPMC12621910 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature