Retrograde mitochondrial transport regulates mitochondrial biogenesis in zebrafish neurons.

ABSTRACT: To maintain a healthy mitochondrial population in a long-lived cell like a neuron, mitochondria must be continuously replenished through the process of mitochondrial biogenesis. Because the majority of mitochondrial proteins are nuclear encoded, mitochondrial biogenesis requires nuclear sensing of mitochondrial population health and function. This can be a challenge in a large, compartmentalized cell like a neuron in which a large portion of the mitochondrial population is in neuronal compartments far from the nucleus. Using in vivo assessments of mitochondrial biogenesis in zebrafish neurons, we determined that mitochondrial transport between distal axonal compartments and the cell body is required for sustained mitochondrial biogenesis. Estrogen-related receptor transcriptional activatio

SUBMITTER: Lang AE 

PROVIDER: S-EPMC12621953 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature