Ridge-assisted Micro Positioning of Cells and Particles in a Microchannel.

ABSTRACT: The capability to deterministically and precisely control the lateral position of focused cell streams in a microchannel provides diverse opportunities for biomedical applications, including cell concentration, imaging flow cytometry, and cell-based liquid biopsy platforms. Inertial microfluidics introduced various high-throughput strategies for ordering particles and cells within microchannels. However, existing approaches do not permit precise control over the lateral focusing position of cells. By leveraging engineered microvortices generated by channel ridges and fluidic lift forces, we present a microfluidic method for deterministically positioning focused cell streams to desired lateral streamlines. Unlike inertial focusing, the ridge-assisted micro positioning (RAMP) is independent

SUBMITTER: Payan-Medina A 

PROVIDER: S-EPMC12621959 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature