Independent Associations of Sleep and Walking with Cognition in Parkinson's Disease: A Perivascular Spaces Analysis.

ABSTRACT: Perivascular spaces (PVSs) support brain waste clearance and are influenced by sleep. In Parkinson's disease (PD), sleep is often disrupted, and can co-occur with gait dysfunction. This study investigated how sleep disruption, walking difficulties, and cognition relate in PD, considering PVS as a mediator. Our cohort included 348 participants -healthy controls (HC, n=59), prodromal (n=117), and PD patients (n=172)- in the Parkinson's Progression Markers Initiative (PPMI) study. Insomnia and walking issues were assessed by questionnaire, cognition was measured with the Symbol Digit Modalities (SDM) test, and PVS volume fraction in white matter (WM-PVS) and basal ganglia (BG-PVS) was quantified. PVS did not mediate the relationship between sleep or motor problems, on cognition. Walking diffi

SUBMITTER: Sibilia F 

PROVIDER: S-EPMC12622019 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature