NK cell allorecognition shapes reprogramming of neutrophils infiltrating heart allografts.

ABSTRACT:

Background

Recent developments in neutrophil biology have demonstrated that neutrophils are phenotypically and functionally heterogeneous. Tissue microenvironments dictate changes in neutrophil cell states in infection and cancer, but little is known about how alloimmune responses or solid organ transplantation influence neutrophil heterogeneity and plasticity.

Methods

Here, we used the murine heterotopic heart transplant model in conjunction with high dimensional flow cytometry and transcriptome analysis to interrogate how the alloimmune response and microenvironment of a transplanted organ influence neutrophil subset differentiation and plasticity. Complete MHC mismatched A/J (H2^a) or syngeneic B6 (H2^b) hearts were transplanted to C57BL/6 or B6 backgr

SUBMITTER: Koritzinsky EH 

PROVIDER: S-EPMC12622040 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature