Cyclic lipopeptide natural products as taxa-specific antibacterial inhibitors of the lipid II flippase.

ABSTRACT: Antimicrobial resistance (AMR) is an existential threat to modern healthcare; one fueled by selection pressure provided by the use of broad-spectrum antibiotics in medicine and agriculture. As these antibiotics rely on a small set of chemical scaffolds and affect an even smaller number of biological targets, emergent AMR genes can spread through microbiomes to simultaneously inactivate multiple classes and generations of drugs. Long-overlooked for their perceived clinical limitations, antibacterial natural products with taxa-specific activities now present an underexplored source of design principles for precision antibiotics that can selectively eliminate individual microbes and limit community-wide incentives for AMR. Here, we present our re-investigation of one such taxa-specific antiba

SUBMITTER: Barrois EB 

PROVIDER: S-EPMC12622048 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature