Reply to: The chemotherapeutic drug CX-5461 is a potent mutagen in cultured human cells.

ABSTRACT: Replying to GCC Koh et al., Nature Genetics (www.nature.com/articles/s41588-023-01602-9) and the comments by Simon Boulton in Nature Genetics (www.nature.com/articles/s41588-023-01611-8). The drug CX-5461 [Pidnarulex] is an inhibitor of RNA polymerase I and topoisomerase II and a DNA G-quadruplex stabilizer. Koh et al. recently reported that CX-5461 induces extensive, non-selective collateral mutagenesis in vitro at magnitudes surpassing known environmental carcinogens, raising concerns about its potential to promote secondary cancers. Mindful that the report of Koh et al. was exclusively an in vitro study, we applied the same ultra-sensitive, error-corrected TwinStrand Duplex Sequencing approach and analyses (methods) to a longitudinal series of clinical specimens from four

SUBMITTER: Kanwal S 

PROVIDER: S-EPMC12622090 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature