Multi-ancestral genome-wide study of chronic pain reveals widespread genetic correlations with mental and physical health traits.

ABSTRACT: Chronic pain (CP) is a debilitating condition that impacts an individual's physical and mental health. CP is common, affecting around 12-40% of individuals across the world. In this study, we conducted a genome-wide association study (GWAS) of lifetime incidence of CP in the All of Us Research Program, across six different ancestries in the United States (total N_case = 137 043, total N_control = 154 038). We found one genome-wide significant locus in the cross-ancestry meta-analysis on chromosome 5 (lead SNP: rs1196962975, p = 4.53E-08). Additionally, one locus on chromosome 11 (lead SNP: rs5795684) reached genome-wide significance in the admixed genetic ancestry sample (p = 1.13E-08). Cross-ancestry genetic correlations ranged from 0.40 - 0.78. CP was ge

SUBMITTER: Romero Villela PN 

PROVIDER: S-EPMC12622132 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature