Lactoferrin levels in cerebrospinal fluid exhibits isoform-specific associations with Alzheimer's disease.

ABSTRACT:

Background

Pathological changes in Alzheimer's disease (AD) begin years before the onset of clinical symptoms. Developing cost-effective and minimally invasive biomarkers for preclinical diagnosis remains a critical goal in the field. Lactoferrin, an iron-binding glycoprotein, has emerged as a promising candidate due to its multifunctional roles reported in previous studies. However, whether lactoferrin levels in biofluids are associated with established AD biomarkers, and whether it can serve as a reliable diagnostic indicator, remains controversial.

Methods

We analyzed SOMAscan proteomic data from 1,367 paired plasma and cerebrospinal fluid (CSF) samples from the ACE Alzheimer's Center Barcelona cohort to evaluate lactoferrin levels. Associations between two lactoferrin-ta

SUBMITTER: Zhao F 

PROVIDER: S-EPMC12622143 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature