Epigenetic clocks of biological aging and risk of incident mild cognitive impairment and dementia: the Women's Health Initiative Memory Study.

ABSTRACT: Aging is the strongest risk factor for dementia; however, few studies have examined the association of biological aging with incident dementia. We analyzed 6,069 cognitively unimpaired women (mean age=70.0 ± 3.8 years) in the Women's Health Initiative Memory Study to examine the association of accelerated biological aging, measured with second and third-generation epigenetic clocks (AgeAccelPheno and AgeAccelGrim2, and DunedinPACE, respectively) with incident mild cognitive impairment (MCI) and probable dementia. Multivariable Cox proportional hazards models adjusted for age, race, ethnicity, smoking, hormone therapy regimen, physical activity, body mass index, and estimated white blood cell counts. For comparison, we also examined first-generation epigenetic clocks (AgeAccelHorvath; AgeAc

SUBMITTER: Nguyen S 

PROVIDER: S-EPMC12622145 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature