Targeting methicillin-resistant <i>Staphylococcus aureus</i>: The comprehensive action of ent-kaurane diterpenoids on bacterial integrity.

ABSTRACT: Methicillin-resistant Staphylococcus aureus (MRSA) represents a considerable challenge to global health owing to its resistance to antibiotics. In our prior research, we identified four ent-kaurane diterpenoids (compounds 1-4) isolated from Siegesbeckia orientalis L., which exhibited anti-MRSA activity. Nevertheless, the precise mechanisms by which these compounds exert their effects remain to be fully elucidated. This study aims to comprehensively evaluate the anti-MRSA properties and explore the biological processes associated with the activity of compounds 1-4. We utilized the minimum broth dilution method, electron microscopy, and membrane integrity assays to demonstrate that these compounds inhibit the growth of MRSA by disrupting cell wall and membrane str

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12622317 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature