Innate immuno-response to nanoparticle uptake in liver and spleen mimics pathogen infection.

ABSTRACT:

Background

Systemically administered nanoparticles (NPs) designed for biomedical applications are retained in liver and spleen where they become rapidly phagocyted by tissue macrophages leading to inflammation.

Methods

To gain insight into the NP-immune cell interaction in liver spleen and lungs, we followed the distribution of molybdenum nanoparticles (MoNPs) in vivo by X-Ray Fluorescence Imaging (XRF) and examined the NP-macrophage interaction and physiological response in these organs.

Results

XRF imaging showed that intravenously administered MoNPs transiently accumulate in lungs, liver, and spleen. This leads to increments in the number of Kupffer cells (KC), natural killer (NK) cells, oxidative stress, and inflammation. Macrophage phenotype switched from

SUBMITTER: Brodin BA 

PROVIDER: S-EPMC12622318 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature