Innate immunity pathways activate cell proliferation after penetrating traumatic brain injury in adult <i>Drosophila</i>.

ABSTRACT: We are utilizing an adult penetrating traumatic brain injury (PTBI) model in Drosophila to investigate regenerative mechanisms after damage to the central brain. Here, we focus on cell proliferation as an early event in the regenerative process. To identify pathways that could trigger cell proliferation following PTBI, we utilized bulk RNA-Seq. We find that transcript levels for components of both Toll and Immune Deficiency (Imd) innate immunity pathways are rapidly and highly upregulated post-PTBI. We then tested mutants for the NF-κB transcription factors of the Toll and Imd pathways, Dorsal-related immunity factor (Dif) and Relish (Rel), respectively. We find that loss of either Dif or Rel results in loss of cell proliferation after injury and identify tissue-specific requirements for D

SUBMITTER: Ahern-Djamali S 

PROVIDER: S-EPMC12622319 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature