Electron Transfer-Tailored D-Band Center to Boost Nanozyme Catalysis for Interpretable Machine Learning-Empowered Intelligent Biosensing.

ABSTRACT: The escalating global burden of infectious diseases demands biosensing technologies that transcend the complexity-sensitivity-accuracy trade-off in real-world applications. Herein, an interpretable machine learning-empowered multimodal biosensor synergizing electron transfer-enhanced nanozymes and aggregation-induced emission luminogens (AIEgens) for ultrasensitive pathogen detection is presented. By engineering aminophenol formaldehyde resin nanobowls anchored with monodisperse Pt nanoparticles, interfacial electron transfer (N→Pt→O) induces an upshift of Pt d-band center relative to the Fermi level, as validated by density functional theory. This electronic modulation optimizes H₂O₂ adsorption energy, lowers the energy barrier of the rate-determining step, and reduc

SUBMITTER: Li Y 

PROVIDER: S-EPMC12622424 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature