Bacteria-Targeted Single-Atom Nanozyme With Photothermal-Augmented Multi-Enzymatic Cascade and NO Delivery for Enhanced Infected Wound Healing.

ABSTRACT: Infected diabetic wound management confronts significant challenges, including bacterial resistance, oxidative stress, and impaired vascular repair, resulting in substantial unmet clinical needs. To address these issues, a multifunctional therapeutic nanoplatform, mCu-SAE@BNN6@PEG-Van (CBPV), is developed by sequentially functionalizing mesoporous copper single-atom nanozymes (mCu-SAE) loaded with the nitric oxide (NO) donor BNN6 and vancomycin-conjugated polyethylene glycol (PEG-Van). CBPV integrates three synergistic therapeutic modalities: 1) pathogen-specific targeting via Van-mediated bacterial recognition; 2) NIR-II photothermally enhanced catalytic therapy via Cu-N₃ centers in mCu-SAE, generating reactive oxygen species; 3) photoactivated NO release from BNN6, enabling pe

SUBMITTER: Chen J 

PROVIDER: S-EPMC12622438 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature