Neurophilic Biomimetic Lipoprotein-Mediated Targeted Nerve Growth Factor Delivery for Traumatic Brain Injury Therapy.

ABSTRACT: Traumatic brain injury (TBI) induces neuronal death, inflammation, and neurological dysfunction. Although nerve growth factor (NGF) possesses neuroprotective potential, its clinical use is hindered by poor blood-brain barrier (BBB) permeability and insufficient neural targeting. Here, a neurophilic biomimetic lipoprotein for brain-targeted NGF delivery is developed: 1) a matrix-like core (Nc) that preserves NGF bioactivity; 2) an ApoE3-reconstituted high-density lipoprotein shell (Nc-rHDL) to enhance BBB penetration; 3) an αRDP peptide-modified version (Nc-rHDL@P) to improve neural targeting. In vitro BBB models and controlled cortical impact (CCI) mice demonstrate that Nc-rHDL@P efficiently crossed the BBB and selectively accumulated around injured regions. The engineered Nc-rHDL@P signif

SUBMITTER: Huang J 

PROVIDER: S-EPMC12622449 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature