A Dual-Target Recognition System Based on Acid-Degradable Ni-MOF and Aptamer Guidance for Precise Tumor Diagnosis and Combined Therapy.

ABSTRACT: Inherent heterogeneity of tumors significantly limits the therapeutic efficacy of existing cancer treatment systems. This work proposes a dual-targeting theranostic system based on acid-responsive cleavage of a metal-organic framework (MOF). By functionalizing the MOF with dual aptamers that exhibit strict base complementarity to cancer cell biomarkers, the system achieves synergistic passive and active targeting, significantly improving the recognition accuracy for cancer cells. Simultaneously, leveraging the glucose-dependent metabolic features of tumor cells, the system efficiently catalyzes the generation of hydroxyl radicals (·OH) from glucose, thereby activating chemodynamic therapy. Furthermore, under infrared light irradiation, nickel (Ni) atoms doped within the MOF generate a phot

SUBMITTER: Xu J 

PROVIDER: S-EPMC12622455 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature