AGAPIR: A Novel PIWI-Interacting RNA Enhancing Post-Decompression Angiogenesis in Degenerative Cervical Myelopathy.

ABSTRACT: Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord dysfunction worldwide. Although surgical decompression can halt disease progression and improve neurological function in most patients, there remains a subset for whom functional improvement is limited. Impaired spinal cord perfusion is a pathological hallmark of DCM, which highlights the importance of restoring blood flow to enhance neurological outcomes. Here, this work identifies a novel angiogenesis-associated PIWI-interacting RNA (AGAPIR) that enhances angiogenesis and motor function following spinal cord decompression. Using piRNA sequencing, this work identifies AGAPIR as a key regulator of DCM pathogenesis. This work observes significant upregulation of AGAPIR expression in the spinal cord following surg

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12622476 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature