Enantioselective Alkoxycarbonyl-Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis.

ABSTRACT: The synthesis of ester derivatives represents one of the most significant and fundamental tasks in modern organic chemistry, and numerous methods have been developed in both academic and industrial contexts. Among these, alkoxycarbonyl radical-mediated functionalization strategies have emerged as a highly efficient and versatile tool for the synthesis of these compounds. Despite the significant advancements in recent years, the radical-induced enantioselective alkoxycarbonylation reaction remains largely unexplored. Herein, a highly enantioselective alkoxycarbonyl-lactonization of alkenes is reported through a photoredox/copper dual-catalyzed alkoxycarbonyl radical addition/cyclization reaction. With this approach, a diverse array of ester-substituted chiral γ-butyrolactones bearing a quat

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC12622489 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature