Engineering Neutrophil Vesicles for Synergistic Protection against Ischemia/Reperfusion Injury after Lung Transplant.

ABSTRACT: Lung transplantation (LTx) is a life-saving procedure for patients with end-stage respiratory failure; however, primary graft dysfunction (PGD), primarily induced by ischemia/reperfusion injury (IRI), remains a major complication. Although ex vivo lung perfusion (EVLP) improves preservation, clinical translation remains challenging owing to IRI complexity. Here, a novel approach is presented to mitigate lung IRI by developing of neutrophil-derived ROS-responsive cellular vesicles (SOD2-Fer-1@CVs). This hybrid system integrates superoxide dismutase 2 (SOD2)-overexpressing neutrophil nanovesicles with ROS-responsive liposomes loaded with ferrostatin-1 (Fer-1), a potent ferroptosis inhibitor. SOD2-Fer-1@CVs enabled targeted delivery to inflamed tissues and high oxidative stress environments,

SUBMITTER: Yuan HX 

PROVIDER: S-EPMC12622495 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature