An Injectable Zwitterionic Hydrogels with Multiple Intermolecular Interactions for Effective Prevention of Abdominal Adhesions.

ABSTRACT: Postoperative abdominal adhesions are the most common complication following abdominopelvic surgery, posing a significant burden on patients, clinicians, and society. However, current physical barriers often involve a tradeoff between preventing these adhesions and inhibiting inflammation. Herein, a one-stone-two-birds strategy is presented to address this challenge through an injectable intertwined hydrogel containing sulfobetaine, modified aminocaproic acid (A6ACA), and ZnO nanoparticles (PSA-ZnO hydrogel). This intertwined network is stabilized by multiple intermolecular coordination bonds, including hydrogen bonds and electrostatic interactions-enabling facile injection and resistance to abdominal creep stress. Experimental results demonstrate that PSA-ZnO hydrogel fully reduce the sev

SUBMITTER: Wen N 

PROVIDER: S-EPMC12622508 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature