Integrating UPLC-Q-TOF-MS and network pharmacology to analyze the components and mechanism of action of Compound Duzhong Zhuangyao Capsules on osteoporosis.

ABSTRACT: Although Compound Duzhong Zhuangyao Capsules (Co-DZZY Capsules) are used to treat lumbago and knee weakness caused by osteoporosis (OP), the underlying mechanisms involved remain unclear. Therefore, this study aimed to investigate the active components of Co-DZZY Capsules and the involved mechanisms for the treatment of OP. The components of the Co-DZZY Capsules were tentatively identified using ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry, and their targets were retrieved from the Swiss Target Prediction database. OP-related targets were obtained from the Gene Cards database. A protein-protein interaction network was constructed using the STRING data platform, and the compound-target-disease visualization network was established using Cytoscap

SUBMITTER: Qiu L 

PROVIDER: S-EPMC12622607 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature