Genetic causal association between metabolic syndrome and idiopathic pulmonary fibrosis: A 2-sample Mendelian randomization.

ABSTRACT: Prior epidemiological investigations have indicated a linkage between metabolic syndrome (MetS) and idiopathic pulmonary fibrosis (IPF). The objective of the present research was to elucidate the inherited causal relationship of MetS with IPF. A 2-sample Mendelian randomization (MR) design was adopted to assess the genetic cause-effect link between MetS and IPF. Multiple analytical strategies, such as inverse-variance weighted (IVW), MR-Egger, weighted median, and weighted mode, were implemented. Outlier evaluation was carried out through a leave-one-out analysis. MR-PRESSO and the MR-Egger intercept test were undertaken to reduce the influence of horizontal pleiotropy. Heterogeneity was appraised using Cochran's Q statistic. IVW analysis suggested a potential causal association between wa

SUBMITTER: Liu Q 

PROVIDER: S-EPMC12622708 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature