Rheumatoid arthritis increases risk of atherosclerosis: A Mendelian randomization study.

ABSTRACT: Understanding of the relationship between rheumatoid arthritis (RA) and atherosclerosis (AS) remains limited by the shortcomings of previous observational studies. This study investigated the causal relationship between RA and AS risks using Mendelian randomization (MR) analysis. Genetic data related to RA and AS were sourced from the genome-wide association studies database and FinnGen Biobank gene database, respectively. Standard screening metrics were applied and palindromic single nucleotide polymorphisms were processed. The initial analysis employed the inverse-variance weighted method for MR analysis, with other methods used as supplementary methods. Multiple sensitivity analyses, including MR-Egger and MR-PRESSO, were used to ensure the robustness of the study. The RA-related datase

SUBMITTER: Liu QP 

PROVIDER: S-EPMC12622715 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature