Exploring the causal relationship between gut microbiota and thromboembolism: A Mendelian randomization study.

ABSTRACT: Although several studies have indicated potential associations between gut microbiota (GM) and thromboembolic diseases, the causative role of GM in thromboembolism remains unclear. We employed two-sample Mendelian randomization (MR) analysis to investigate the potential causal association between GM and 3 thromboembolic conditions: arterial embolism and thrombosis (AET), venous thromboembolism (VTE), and pulmonary embolism (PE). Genome-wide association study datasets from MiBioGen and FinnGen were utilized, with GM serving as the exposure and thromboembolism outcomes as endpoints. Using the inverse-variance weighted approach, under conditions without heterogeneity or horizontal pleiotropy, 16 gut microbial genera were significantly associated with thromboembolic risks. Specifically, Holdem

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12622754 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature