Baseline and longitudinal changes in cortical thickness and hippocampal volume predict cognitive decline.

ABSTRACT: BackgroundAs we transition to disease-modifying treatment for Alzheimer's disease (AD), identifying individuals most at risk for future cognitive decline is crucial. Amyloid PET, cerebrospinal fluid and more recently blood-based biomarkers can identify the first stage of AD. However, changes detectable by PiB-PET may precede the onset of the dementia by 20-30 years. MRI is a widely available tool for detecting longitudinal changes in brain structure, such as cortical thickness and hippocampal volume and may provide additional insight into which patients are at greatest risk to develop cognitive decline.ObjectiveTo determine how well the hippocampal volume and cortical thickness, without specific AD biomarkers, can predict cognitive decline.MethodsMRI data from 344 participants (cognitively

SUBMITTER: Chen G 

PROVIDER: S-EPMC12622766 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature