Analysis of categorical data from biological experiments with logistic regression and CMH tests.

ABSTRACT: The choice of appropriate statistical tests in experimental biology is critical for scientific rigor and can be challenging in the case of categorical data analysis. Using example datasets from Caenorhabditis elegans research, we conduct statistical analysis of (1) a rare cellular event involving the formation of a neuronal extrusion called an exopher and (2) a variable behavioral response across time. We employ the Cochran-Mantel-Haenszel (CMH) test and logistic regression for analysis. Recognizing there are potential accessibility issues using logistic regression, we provide step-by-step tutorials and example code. We emphasize that logistic regression can handle both simple and complex multivariable datasets; logistic regression can also provide more comprehensive insights into experime

SUBMITTER: Androwski RJ 

PROVIDER: S-EPMC12622779 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature