St John's Wort (Hypericum perforatum) Fresh Plant Tincture for Patients with Mild to Moderate Depression: A Prospective Observational Study.

ABSTRACT:

Introduction

High-dose dry extract preparations of St John's wort (Hypericum perforatum) (hd-SJW) are equally effective as synthetic antidepressants (SAD) for mild to moderate depression as shown by various randomized controlled trials (RCTs). Other available preparations of SJW such as fresh plant tinctures are dosed lower and no clinical study about their effect has been published so far. The aim of this study was to evaluate the effect of a SJW fresh plant tincture (C-SJW-ft) on depressive symptoms and its tolerability in patients comparable to patients reported in hd-SJW RCTs applying the same outcome, the Hamilton Depression Scale 17 (HAM-D 17).

Methods

Prospective observational study of outpatients with mild to moderate depressive episodes (ICD-10/DSM-IV) treated with

SUBMITTER: Kalbermatten N 

PROVIDER: S-EPMC12622987 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature