Study Protocol of the 10-Year Longitudinal Amersfoort Cohort Study on Functional Decline, Healthy Aging, and Frailty (AMCOHF) in a Community-Dwelling Older Population.

ABSTRACT:

Introduction

Frailty, characterized by a reduction in intrinsic capacity across multiple physiological systems, is a key concern in healthy aging. Insight in the trajectory of an individual's functional ability and intrinsic reserve capacity in a relatively younger population of older adults is lacking. This study aims to investigate the early stages of frailty by tracking trajectories of physical indicators of intrinsic capacity before frailty becomes clinically evident.

Methods

The AMersfoort COhort study on functional decline, Healthy aging and Frailty (AMCOHF) is a unique 10-year prospective cohort study evaluating the predictive value of longitudinal trajectories of physical parameters for frailty onset or robustness maintenance. An a-select community-dwelling robust po

SUBMITTER: Houtkamp D 

PROVIDER: S-EPMC12622989 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature