Canine endometrial organoids respond to exogenous steroid hormones and are an in vitro model for cystic endometrial hyperplasia.

ABSTRACT:

Graphical abstract

Abstract

The etiology, epidemiology, and pathogenesis of many uterine diseases, including endometritis, cystic endometrial hyperplasia (CEH), and pyometra, remain poorly understood in canids, hindering the advancement of effective preventative therapeutics to ultimately improve fertility. The development of an in vitro endometrial cell culture system that mimics in vivo architecture, cellular morphology, and physiological responses would facilitate a greater understanding of the mechanisms of complex canine uterine diseases and reduce the need for in vivo research. Three-dimensional organoid cell cultures may provide an innovative approach for studying uterine pathologies in the bitch. Unlike traditional two-dimensional monolayer cell culture systems, org

SUBMITTER: Thompson RE 

PROVIDER: S-EPMC12623135 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature