Collagen-ORC Versus Standard Treatment in Diabetic Foot Ulcers: A Systematic Review and Meta-Analysis of Randomised Trials.

ABSTRACT: Diabetic foot ulcers (DFUs) are a major cause of infection, hospitalisation, and amputation. Collagen-based dressings-especially collagen combined with oxidised regenerated cellulose (ORC)-are proposed to improve healing by modulating matrix metalloproteinases (MMPs), stabilising the extracellular matrix (ECM), and tempering inflammation; some formulations also include antimicrobial or bioactive adjuncts. We conducted a systematic review of randomised controlled trials (RCTs) following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidance. Adults with DFUs were eligible. Interventions included collagen-alone or collagen-combination dressings (e.g., collagen-oxidised regenerated cellulose [collagen-ORC]/silver, collagen-chitosan) versus standard of care (SOC)

SUBMITTER: Theodorakopoulos G 

PROVIDER: S-EPMC12623144 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature