Mesoscopic vascular alterations in Alzheimer's disease.

ABSTRACT:

Introduction

Cerebrovascular alterations are associated with the pathology of Alzheimer's disease (AD). Yet, the role of these alterations is not fully understood, partly due to a paucity of data from mesoscopic vasculature (24-240 µm diameter).

Methods

We used label-free, serial-sectioning optical coherence tomography to reconstruct mesoscopic cerebrovasculature of the dorsolateral prefrontal cortex (DLPFC) samples from AD and control subjects. We quantified three-dimensional alterations to the vascular networks and measured the correlations between vascular alterations and deposits of amyloid β protein (Aβ) and phosphorylated tau protein (p-tau).

Results

The AD group had significantly reduced volume fraction, vessel length density, and branch density. There were neg

SUBMITTER: Hyman M 

PROVIDER: S-EPMC12623155 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature