Ketogenic diet-induced changes in methylation status and neuropeptide signaling: relationships between S-adenosylmethionine (AdoMet), orexin-A, and metabolic health.

ABSTRACT:

Introduction

S-Adenosylmethionine (AdoMet) is the principal methyl donor in numerous biochemical reactions, regulating lipid and glucose metabolism, inflammatory pathways, and neurotransmitter synthesis. Orexin-A, a hypothalamic neuropeptide involved in arousal, feeding behavior, and energy expenditure, plays a crucial role in metabolic homeostasis. Emerging evidence suggests potential crosstalk between methylation pathways and orexinergic signaling; however, this interaction has not been explored in the context of nutritional ketosis. This study aimed to evaluate the effects of a structured ketogenic dietary intervention on circulating AdoMet, Orexin-A, and key metabolic parameters.

Methods

Twenty-one adults (11 males, 10 females) were recruited from the Unit of Dietetics,

SUBMITTER: Mosca L 

PROVIDER: S-EPMC12623159 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature