The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome.

ABSTRACT:

Background

Oxidative stress and metabolic disorders significantly contribute to the development of polycystic ovarian syndrome (PCOS). Heme oxygenase-1 (HMOX1) plays a key role in the degradation of heme and the regulation of oxidative stress, ferroptosis, and glycolipid metabolism. This study explored the relationship between HMOX1 promoter T-413A single nucleotide polymorphism (SNP, rs2071746), (GT)n dinucleotide repeat variant (rs3074372), plasma HMOX1 levels, and the risk of PCOS in Chinese women.

Methods

This case-control study included 1092 women diagnosed with PCOS and 805 controls. The (GT)n and rs2071746 polymorphisms were identified using polymerase chain reaction amplification, followed by capillary electrophoresis or restriction fragment length polymorphis

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12623185 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature