Uncovering the new landscape of leukoaraiosis through the circular RNA-miRNA-mRNA axis.

ABSTRACT:

Background

White matter disease arises from the loss of oligodendrocyte progenitor cells and is associated with adverse outcomes in leukoaraiosis (LA) patients. Although the regulatory roles of circ-RNA/miRNA/mRNA in brain disorders are well-documented, their impact and mechanisms in white matter injury (WMI) remain unclear. This study aimed to investigate the involvement of hsa_circ_0018401/miR-145-5p/AIFM1 axis in white matter injury.

Method

Whole blood samples from LA patients underwent quantitative real-time polymerase chain reaction (qRT-PCR) to evaluate the expression levels of circular RNA and miRNA. Bioinformatics tools were employed to predict the downstream miRNA. Primary oligodendrocyte progenitor cells (OPCs) were isolated from rats. The downstream miRNA, miR-145

SUBMITTER: Zhu C 

PROVIDER: S-EPMC12623190 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature