Ferritin nanoparticle vaccine displaying optimized spike protein confers broad protection against Omicron subvariants.

ABSTRACT:

Introduction

The newly emerged Omicron subvariants demonstrate resistance to current therapeutic antibodies and an enhanced ability to evade the vaccine-induced immune responses. Among them, JN.1 sublineages are considered highly immune-evasive, underscoring the urgent need for broadly protective vaccines. Ferritin nanoparticles, with their unique hollow nanocage structure, provide an efficient antigen-display platform for next-generation vaccine development.

Methods

Based on the previously constructed Delta-6P-S recombinant protein vaccine with broad-spectrum protective effects, this study optimized the S protein structure displayed on the surface of ferritin nanoparticles by comparing the immune responses induced in C57BL/6J mice.

Results

Delta-4S1158 nanoparticles,

SUBMITTER: Feng S 

PROVIDER: S-EPMC12623353 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature