Association between dietary choline intake and odds of preeclampsia: a case-control study.

ABSTRACT:

Background

Preeclampsia (PE) is a leading cause of maternal and perinatal morbidity and mortality. Choline, essential in one-carbon metabolism and vascular function, may influence placental health. We examined associations of total, subtype-, and source-specific dietary choline with PE odds in Chinese women.

Methods

We conducted a 1:1 matched case-control study of 982 pregnant women (491 PE cases; 491 controls) in Zhengzhou, China. Dietary intake over the preceding three months was assessed using a validated semi-quantitative food-frequency questionnaire. Conditional logistic regression calculated odds ratios (ORs) and 95% confidence intervals (CIs) for total choline, lipid- vs. water-soluble forms, and animal- vs. plant-derived sources, adjusting for covariates. Restricted

SUBMITTER: Zhu J 

PROVIDER: S-EPMC12623378 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature